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Circulating progenitor cells decrease immediately after marathon race in advanced-age marathon runners.

Volker Adams¹, Axel Linke, Frank Breuckmann

¹Department of Cardiology, University Leipzig-Heart Center, Leipzig, Germany. adav@medizin.uni-leipzig.de

European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology

|August 30, 2008

Summary

This summary is machine-generated.

Marathon running significantly decreases circulating hematopoietic stem cells in older adults, despite no change in endothelial progenitor cells (EPCs). This suggests an inflammatory response and potential stem cell differentiation post-race.

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Area of Science:

Exercise physiology
Stem cell biology
Gerontology

Background:

Exercise is known to mobilize progenitor cells from bone marrow.
The impact of strenuous exercise on circulating progenitor cells remains unclear.
This study investigates marathon running's effect on progenitor cells in older runners.

Purpose of the Study:

To examine the influence of marathon running on circulating progenitor cells.
To assess changes in hematopoietic stem cells and endothelial progenitor cells (EPCs) post-race.
To analyze vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) levels after a marathon.

Main Methods:

Included 68 healthy marathon runners (average age 57 years).
Quantified circulating progenitor cells (CD34, CD117, CD133, EPCs) using fluorescence-activated cell sorting (FACS).
Measured VEGF and EGF levels via enzyme-linked immunosorbent assay (ELISA).

Main Results:

Marathon running significantly increased white blood cell count.
A significant decrease was observed in CD34, CD117, and CD133 cells post-race.
No significant change in endothelial progenitor cells (EPCs) was detected; VEGF levels decreased, while EGF levels remained unchanged.

Conclusions:

Marathon completion triggers an inflammatory response and downregulates circulating hematopoietic stem cells.
Endothelial progenitor cell (EPC) levels did not change, possibly due to increased differentiation of remaining CD34 cells.
Strenuous endurance exercise impacts stem cell populations differently in advanced-aged runners.