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Related Experiment Videos

Bacterial translocation in trauma patients.

A B Peitzman1, A O Udekwu, J Ochoa

  • 1Department of Surgery, University of Pittsburgh School of Medicine, Pennsylvania 15261.

The Journal of Trauma
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

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Bacterial translocation to mesenteric lymph nodes (MLNs) is uncommon in trauma patients, even with severe injuries. This study found no link between MLN bacterial presence and sepsis or organ failure in critically ill trauma survivors.

Area of Science:

  • Trauma critical care
  • Gastroenterology
  • Infectious disease

Background:

  • Sepsis and multiple system organ failure (MSOF) are significant causes of death in trauma patients.
  • Bacterial translocation from the gut is a known phenomenon, often studied in laboratory settings.
  • Its incidence and clinical relevance in critically ill trauma patients remain unclear.

Purpose of the Study:

  • To evaluate the incidence of bacterial translocation to mesenteric lymph nodes (MLNs) in critically ill trauma patients.
  • To determine the relationship between MLN bacterial translocation and subsequent sepsis or MSOF.
  • To compare findings in trauma patients with those undergoing laparotomy for gastrointestinal disease.

Main Methods:

  • Prospective evaluation of 29 critically ill patients (25 trauma, 4 GI disease).

Related Experiment Videos

  • Collection of mesenteric lymph node (MLN) cultures during surgery or exploration.
  • Correlation of MLN culture results with clinical outcomes, including sepsis, MSOF, and mortality.

    • Main Results:

    • Bacterial translocation to MLNs occurred in 3 of 4 patients with gastrointestinal disease.
    • No trauma patients (n=25), even after repeat exploration, showed positive MLN cultures.
    • Infectious complications and patient outcomes were not associated with MLN culture findings.

    Conclusions:

    • Bacterial translocation to MLNs is not a frequent event in acutely injured trauma patients.
    • The typical gut-to-bloodstream bacterial progression via MLNs may necessitate prolonged periods and gut mucosal damage.
    • Findings suggest current models of bacterial translocation may not fully represent the acute trauma setting.