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Cell Subtype-specific Analysis of Neuronal Membrane Proteasome in Somatosensory Neurons

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Elevated B6 levels and peripheral neuropathies.

K Scott¹, S Zeris, M J Kothari

¹Department of Neurology, Pennsylvania State College School of Medicine, Hershey, PA 17033, USA.

Electromyography and Clinical Neurophysiology

|August 30, 2008

Summary

This summary is machine-generated.

High vitamin B6 (pyridoxine) levels can cause sensory neuropathy. This study found elevated pyridoxine in 26 patients, with symptoms like numbness and burning, suggesting it as a potential cause of neuropathy.

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Published on: November 9, 2017

Area of Science:

Neurology
Clinical Medicine
Nutritional Science

Background:

Vitamin B6 deficiency is a known cause of polyneuropathy.
The link between elevated pyridoxine (Vitamin B6) levels and neuropathy is less understood.
This study investigates neuropathy in patients with high Vitamin B6 levels.

Purpose of the Study:

To explore the association between elevated serum pyridoxine levels and the development of polyneuropathy.
To identify clinical characteristics and electrodiagnostic findings in patients with hypervitaminosis B6.

Main Methods:

Retrospective review of patients diagnosed with elevated serum Vitamin B6 levels in a neuromuscular clinic.
Analysis of patient-reported symptoms, vitamin usage history, and electrodiagnostic test results (EMG/NCS, quantitative sensory studies).

Main Results:

Twenty-six patients had elevated serum B6 levels (mean 68.8 ng/ml).
Most patients (76.9%) reported daily vitamin intake.
Common symptoms included numbness (96%), burning (49.9%), tingling (57.7%), and balance issues (30.7%).
Abnormal EMG/NCS and quantitative sensory studies were observed in a subset of patients.

Conclusions:

Elevated pyridoxine levels are associated with sensory and sensorimotor polyneuropathy.
Hypervitaminosis B6 should be considered in the differential diagnosis of unexplained polyneuropathy.
Further research is warranted to elucidate the mechanisms of pyridoxine-induced neuropathy.