Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...

Overview of Protein Metabolism

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...

Enteral Nutrition I: Orogastric and Nasogastric Feeding

Enteral Nutrition I: Orogastric and Nasogastric Feeding

Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

Gastrointestinal Motility Disorders

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...

Other Disorders of Digestive System

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pre-Diagnosis Dietary Pattern Differences in Australian Children with Inflammatory Bowel Disease: Exposure Across Ethnicities.

Nutrients·2026

Same author

In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs.

Science immunology·2026

Same author

Liver Transplantation in PNPO Deficiency: Management Challenges and Biological Lessons.

JIMD reports·2026

Same author

Enhancing data compatibility in an evolving landscape: Medical cannabis and polysubstance use protocols in the PhenX Toolkit.

Drug and alcohol dependence·2025

Same author

In vivo reprogramming of cytotoxic effector CD8 <sup>+</sup> T cells via fractalkine-conjugated mRNA-LNP.

bioRxiv : the preprint server for biology·2025

Same author

Subcutaneous infliximab use in children with inflammatory bowel disease in an Australian center.

Journal of pediatric gastroenterology and nutrition·2025

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

Gastrointestinal and nutritional problems in severe developmental disability.

Helen Somerville¹, Gloria Tzannes, Jennifer Wood

¹The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Developmental Medicine and Child Neurology

|August 30, 2008

Summary

Children and adults with severe developmental disabilities frequently experience swallowing and gastrointestinal issues. Interventions improved many, but some required feeding tubes or anti-reflux surgery.

Related Experiment Videos

Last Updated: Jul 2, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

Area of Science:

Gastroenterology
Pediatrics
Neurology

Background:

Severe developmental disabilities often co-occur with complex medical issues.
Swallowing, nutritional, and gastrointestinal problems are common in this population.
Multidisciplinary assessment is crucial for managing these challenges.

Purpose of the Study:

To describe the clinical experience of patients with severe developmental disabilities presenting with swallowing, nutritional, and gastrointestinal issues.
To identify the prevalence of specific conditions such as pulmonary aspiration, chronic esophagitis, and lung disease.
To evaluate the outcomes of interventions in this patient group.

Main Methods:

Retrospective chart review of 452 patients (294 children, 158 adults) over 5 years.
Utilized videofluoroscopy, endoscopy, and computerized axial tomography for diagnosis.
Documented interventions including gastrostomy and fundoplication.

Main Results:

High prevalence of cerebral palsy (approx. 60%) and epilepsy (approx. 60%).
Pulmonary aspiration identified in 41% of children and 47% of adults.
Chronic esophagitis (57% children, 76% adults) and chronic lung disease (94% children, 100% adults) were frequently diagnosed.
Gastrostomy and fundoplication were recommended and performed in a significant number of patients.

Conclusions:

Severe developmental disability is associated with high rates of chronic esophagitis, pulmonary aspiration, and chronic lung disease.
While many patients benefit from conservative management, surgical interventions are sometimes necessary.
Multidisciplinary care is essential for addressing the multifaceted health needs of this population.