Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Introduction to Biological Bases of Psychology

Introduction to Biological Bases of Psychology

Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...

Behavioral Genetics and Its Designs

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

Causes of Social Behavior III: Biological and Environmental Influences

Causes of Social Behavior III: Biological and Environmental Influences

Social behavior is a complex phenomenon that arises from the interaction between biological predispositions and environmental influences. This intricate interplay shapes how individuals think, feel, and act in various social contexts. Understanding these mechanisms requires insights from psychology, neuroscience, genetics, and evolutionary theory.Environmental Influences on Social BehaviorEnvironmental factors, including temperature, odors, and visual stimuli, play a crucial role in shaping...

Biological Influences on Intelligence

Biological Influences on Intelligence

Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter more...

Characteristics of Life

Characteristics of Life

Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...

Nature and Nurture

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

RFC1-related disorders: A case series of 4-aminopyridine and acetyl-DL-leucine treatment.

Cerebellum (London, England)·2026

Same author

Ketamine for negative and depressive symptoms in schizophrenia: the evidence so far.

Frontiers in psychiatry·2026

Same author

Human <i>in vivo</i> assessment of ketamine binding of the serotonin transporter-follow up at a higher dose.

Frontiers in neuroscience·2025

Same author

Genetic predisposition to unwanted side effects under antidepressants and antipsychotics: a molecular-genetic study of 902 patients over 6 weeks.

European archives of psychiatry and clinical neuroscience·2025

Same author

Contribution of Rare and Potentially Functionally Relevant Sequence Variants in Schizophrenia Risk-Locus Xq28,distal.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics·2024

Same author

Morphological correlates of anxiety-related experiences during a ketamine infusion.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2024

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

Decoding Natural Behavior from Neuroethological Embedding

Decoding Natural Behavior from Neuroethological Embedding

Published on: October 3, 2025

Systems biology and complex neurobehavioral traits.

I Giegling¹, A M Hartmann, J Genius

¹Division of Molecular and Clinical Neurobiology, Munich, Germany.

Pharmacopsychiatry

|October 23, 2008

Summary

Schizophrenia has a strong genetic basis, with researchers investigating genetic risk factors through various functional studies. A systems biology approach is crucial for analyzing complex brain data and understanding this complex disease.

More Related Videos

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

Published on: February 26, 2014

Related Experiment Videos

Last Updated: Jul 2, 2026

Decoding Natural Behavior from Neuroethological Embedding

Decoding Natural Behavior from Neuroethological Embedding

Published on: October 3, 2025

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

Published on: February 26, 2014

Area of Science:

Neuroscience
Genetics
Psychiatry

Background:

Schizophrenia exhibits a significant genetic etiology, with heritability estimated around 80% based on family, twin, and adoption studies.
Identifying schizophrenia's genetic risk factors involves linkage and association studies, alongside phenotype refinement through neuropsychology, neurophysiology, imaging, and animal models.

Purpose of the Study:

To explore the functional validation of genes associated with schizophrenia.
To highlight the necessity of advanced data analysis tools for understanding complex brain functions and diseases.

Main Methods:

Functional testing of candidate genes using metabolomics, transcriptomics, proteomics, and transgenic mouse models.
Analysis of protein-protein interactions, allele-specific RNA expression, neuronal and stem cell cultures, post-mortem studies, and rodent behavioral studies.
Application of a systems biology perspective for analyzing structural and functional brain complexity.

Main Results:

Genes associated with schizophrenia require extensive functional validation across multiple biological levels.
Complex datasets generated from these studies necessitate sophisticated analytical approaches.
A systems biology framework offers a promising avenue for dissecting the intricate mechanisms underlying schizophrenia.

Conclusions:

Understanding schizophrenia requires integrating genetic findings with comprehensive functional data.
Advanced analytical tools and a systems biology approach are essential for future research into complex brain disorders.
This integrated approach is pivotal for unraveling the complexities of behavior and disease.