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Related Concept Videos

Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Trichomoniasis01:18

Trichomoniasis

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.

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Related Experiment Video

Updated: Jul 2, 2026

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
07:27

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Published on: December 18, 2012

[Recurrent genital herpes].

Michal Holub1, Klára Labská, Katerina Roubalová

  • 1Department of Infectious Diseases, 1st Medical Faculty, Charles University, Prague, Czech Republic. michal.holub@lf1.cuni.cz

Klinicka Mikrobiologie a Infekcni Lekarstvi
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

Genital herpes infections caused by Herpes simplex virus (HSV) are increasing. While diagnosis and treatment options have improved, new preventive strategies like vaccines are still under development.

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Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Context:

  • Genital herpes infections caused by Herpes simplex virus types 1 and 2 (HSV-1, HSV-2) are increasing.
  • Recurrent genital herpes (GH) often follows primary HSV-2 infection, with HSV-1-induced recurrences being less frequent.
  • Asymptomatic virus shedding is a common occurrence post-primary infection.

Purpose:

  • To review the current landscape of genital herpes diagnosis, treatment, and prevention.
  • To highlight advancements in diagnostic methods and therapeutic approaches.
  • To discuss the ongoing development of novel preventive and therapeutic strategies.

Summary:

  • Diagnostic options for HSV infections have significantly improved, including type-specific antibody testing, viral culture, antigen detection, and polymerase chain reaction (PCR) for viral DNA.
  • Current treatments for recurrent genital herpes in the Czech Republic primarily involve episodic or suppressive antiviral therapy using acyclovir or valacyclovir.
  • Preventive measures are limited, with a focus on pregnant women to mitigate the risk of neonatal disseminated herpes infection.

Impact:

  • Improved diagnostic accuracy allows for timely and appropriate management of HSV infections.
  • Availability of effective antiviral therapies helps control recurrent outbreaks and reduce transmission.
  • Ongoing research into vaccines and novel therapeutics holds promise for future prevention and control of genital herpes.
  • Understanding the epidemiology and clinical manifestations of HSV is crucial for public health interventions.