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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Diversity of Protists III01:27

Diversity of Protists III

Rhizaria are a diverse group of unicellular protists characterized by their threadlike cytoplasmic extensions known as pseudopodia. These structures aid in both locomotion and feeding, giving Rhizaria an amoeboid appearance. Their amoeboid morphology once led to taxonomic confusion, but molecular phylogenetics has clarified their evolutionary placement and emphasized their shared use of pseudopodia despite divergent lineages.This clade comprises diverse lineages such as Chlorarachniophyta,...
Diversity of Archaea III01:27

Diversity of Archaea III

Crenarchaeota, a prominent phylum of Archaea, is remarkable for its ability to thrive in extreme environments characterized by high temperatures and acidity. These microorganisms inhabit sulfuric hot springs, volcanic systems, and submarine hydrothermal vents, where temperatures often exceed 100°C. The unique adaptations of Crenarchaeota not only allow survival under such extreme conditions but also provide insights into the mechanisms of life in primordial Earth-like environments.Morphological...
Cell Diversity01:13

Cell Diversity

The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular organisms...
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...

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Related Experiment Video

Updated: Jul 2, 2026

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
05:48

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

Published on: January 2, 2018

Notch3: from subtle structural differences to functional diversity.

D Bellavia1, S Checquolo, A F Campese

  • 1Laboratory of Molecular Pathology, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Oncogene
|September 2, 2008
PubMed
Summary
This summary is machine-generated.

The Notch3 gene, distinct from other Notch receptors, plays a key role in cell differentiation and disease pathogenesis. Its unique structure influences its nonredundant functions in both human diseases and murine T-cell development.

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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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Area of Science:

  • Molecular Biology
  • Genetics
  • Neuroscience

Background:

  • Notch3 is the third mammalian Notch gene, identified in the early 1990s and initially found in neuroepithelium.
  • Notch3 exhibits structural and functional differences compared to Notch1 and Notch2, despite their high similarity.
  • Unlike Notch1 and Notch2, targeted deletion of murine Notch3 does not result in embryonic lethality due to its restricted tissue distribution.

Purpose of the Study:

  • To review the structural and functional differences of Notch3.
  • To explore the nonredundant roles of Notch3 in disease pathogenesis and T-cell differentiation.
  • To discuss the link between Notch3's structural variations and its functions.

Main Methods:

  • Literature review of studies on Notch3 gene.
  • Analysis of genetic mutations, amplification, and expression deregulation of Notch3.
  • Examination of Notch3's role in murine T-cell differentiation and leukemogenesis.
  • Investigation of Notch3's involvement in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Main Results:

  • Genetic alterations and deregulated Notch3 expression are linked to disrupted cell differentiation in mice.
  • Notch3 mutations are implicated in the pathogenesis of human diseases like CADASIL.
  • Notch3 plays a crucial role in regulating murine T-cell differentiation and leukemogenesis.

Conclusions:

  • Structural differences in Notch3 contribute to its unique, nonredundant functions.
  • Notch3 is a significant factor in the development of specific human diseases and regulates key aspects of murine immune cell development.