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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Negative Regulator Molecules01:23

Negative Regulator Molecules

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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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Scalar and Vector Triple Products01:06

Scalar and Vector Triple Products

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Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
The scalar triple product is the dot product of a vector with the cross product of two vectors....
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Adrenergic Receptors: ɑ Subtype01:31

Adrenergic Receptors: ɑ Subtype

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Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
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Updated: Jan 21, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

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Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype.

M V Giuli1, E Giuliani1, I Screpanti1

  • 1Department of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.

Journal of Oncology
|August 6, 2019
PubMed
Summary
This summary is machine-generated.

Triple-negative breast cancer (TNBC) is aggressive and hard to treat. The Notch signaling pathway is a key driver in TNBC, offering new therapeutic targets for improved patient outcomes.

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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling Pathways

Background:

  • Triple-negative breast cancer (TNBC) lacks targeted therapy options, relying on surgery and chemotherapy with poor prognosis.
  • TNBC accounts for 15%-20% of breast cancer cases and is characterized by aggressive phenotypes.
  • Novel therapeutic targets are urgently needed for TNBC treatment.

Purpose of the Study:

  • To review the specific role of Notch receptors (Notch1-4) in the pathogenesis and progression of TNBC.
  • To identify Notch signaling pathway deregulation as a hallmark of TNBC.
  • To discuss therapeutic strategies targeting Notch receptors for improved TNBC patient outcomes.

Main Methods:

  • Literature review of studies investigating Notch signaling in TNBC.
  • Analysis of the correlation between Notch receptor expression/activation and TNBC phenotypes.
  • Synthesis of current therapeutic approaches targeting the Notch pathway in breast cancer.

Main Results:

  • Notch receptors regulate tumor-initiating cells and mammary cancer stem cells in TNBC.
  • Notch pathway activation correlates with aggressive TNBC characteristics like invasiveness and chemoresistance.
  • Deregulation of Notch signaling is a pathognomonic feature of TNBC.

Conclusions:

  • The Notch signaling pathway is critically involved in TNBC development and progression.
  • Targeting Notch receptors presents a promising therapeutic avenue for TNBC.
  • Further research into Notch-targeted therapies may yield improved prognostic and predictive indicators for TNBC.