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Updated: Jul 2, 2026
08:56
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
Estrogen deficiency and its effect on the jaw bones
Sadakazu Ejiri1, Mikako Tanaka, Naoko Watanabe
1Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, Hozumi, Mizuho, Gifu, Japan. ejiri@dent.asahi-u.ac.jp
Journal of Bone and Mineral Metabolism
|September 2, 2008
Summary
Estrogen deficiency causes significant jaw bone structural changes and bone loss in animal models. This highlights potential links between osteoporosis and dental health, warranting further human research.
Area of Science:
- Dentistry
- Endocrinology
- Orthopedics
Background:
- Postmenopausal osteoporosis is a global health concern.
- Estrogen deficiency leads to bone mass reduction and microarchitectural deterioration.
- The impact of estrogen deficiency on jaw bones is increasingly recognized in dentistry.
Purpose of the Study:
- To review microstructural changes in jaw bones after ovariectomy in animal models.
- To understand the effects of estrogen deficiency on alveolar bone structure.
- To explore the relationship between systemic osteoporosis and jaw bone loss.
Main Methods:
- Review of studies involving ovariectomized animal subjects (rats and monkeys).
- Analysis of microstructural changes in jaw and alveolar bones.
- Investigation of bone resorptive activity and the influence of occlusal hypofunction.
Main Results:
- Estrogen deficiency induced significant structural changes in jaw and alveolar bones of rats and monkeys.
- High bone resorption activity, particularly post-ovariectomy, caused severe bone loss in rat alveolar bone.
- Occlusal hypofunction exacerbated alveolar bone fragility in ovariectomized rats.
- Microstructural damage in monkey alveolar bone correlated with systemic osteoporosis.
Conclusions:
- Estrogen deficiency significantly alters jaw bone structure and increases resorption.
- Findings in animal models suggest a link between systemic osteoporosis and jaw bone loss.
- Further human studies are needed to confirm the association between osteoporosis and human jaw bone loss.
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