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Updated: Jul 2, 2026

Probiotic Studies in Neonatal Mice Using Gavage

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

Probiotic use in the critically ill.

Sunit C Singhi¹, A Baranwal

¹Department of Pediatrics, Advanced Pediatrics Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India. sunit.singhi@gmail.com

Indian Journal of Pediatrics

|September 2, 2008

Summary

This summary is machine-generated.

Probiotics may help critically ill patients by restoring gut health, but current evidence is inconclusive for routine use. More research is needed on optimal strains, dosage, and safety in immunocompromised individuals.

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Area of Science:

Microbiology and critical care medicine
Gut microbiome and host-pathogen interactions
Probiotic research and clinical applications

Background:

Probiotics, live microbes conferring health benefits, are being evaluated for critically ill patients.
Critical illness disrupts gut flora, favoring pathogen growth.
Probiotics aim to normalize gut flora, reduce pathogens, and modulate immunity.

Purpose of the Study:

To evaluate the potential role of probiotics in modifying the gut environment of critically ill patients.
To assess the effectiveness and safety of probiotics in critical care settings.
To identify gaps in knowledge regarding probiotic mechanisms, optimal use, and safety.

Main Methods:

Review of scientific evidence on probiotic use in critically ill patients.
Analysis of probiotic mechanisms, including pathogen reduction and immune modulation.
Examination of clinical outcomes such as infection rates, sepsis, ICU stay, and mortality.

Main Results:

Probiotics are effective in preventing and treating antibiotic-associated diarrhea.
Current probiotic strains and doses may require long-term administration for benefits in critically ill patients.
Evidence is insufficient to recommend routine probiotic use in the critically ill due to inconclusive benefits and safety concerns.

Conclusions:

While probiotics show theoretical benefits, current evidence does not support their routine use in critically ill patients.
Further research is needed on optimal probiotic strains, dosages, and safety profiles, especially in immunocompromised individuals.
Gaps remain in understanding probiotic mechanisms, cost-effectiveness, and risk-benefit ratios in critical care.