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HLA antigens in Brazilian patients with paracoccidioidomycosis

L Z Goldani1, C M Monteiro, E A Donadi

  • 1Department of Internal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Brazil.

Mycopathologia
|May 1, 1991
PubMed

Insights

This study found specific Human Leukocyte Antigen (HLA) types, particularly HLA-B40 and HLA-Cw1, are significantly more common in patients with paracoccidioidomycosis, suggesting a genetic link to the disease.

Area of Science:

  • Immunogenetics
  • Infectious Diseases
  • Human Genetics

Background:

  • Paracoccidioidomycosis is a serious fungal infection.
  • Genetic factors, particularly the Human Leukocyte Antigen (HLA) system, are suspected to influence susceptibility to infectious diseases.

Purpose of the Study:

  • To investigate the association between specific HLA alleles and haplotypes and the genetic susceptibility to paracoccidioidomycosis.
  • To identify potential genetic markers for paracoccidioidomycosis risk.

Main Methods:

  • Human Leukocyte Antigen (HLA) typing was performed on 80 patients with paracoccidioidomycosis for 43 specificities across HLA loci A, B, C, and DR.
  • Frequencies of HLA alleles and haplotypes in patients were compared to those in control subjects.

Main Results:

  • A significantly increased frequency of HLA-B40 (relative risk 29.2) and HLA-Cw1 (relative risk 8.8) was observed in patients.
  • HLA-A2, B7, and B21 frequencies were also elevated in patients.
  • The haplotypes HLA-B40-Cw1 and HLA-A2-B40 showed a positive correlation with the disease.
  • No significant alterations in DR antigen frequencies were found, and no protective HLA effects were identified.

Conclusions:

  • The Human Leukocyte Antigen (HLA) system plays a role in genetic susceptibility to paracoccidioidomycosis.
  • Specific HLA alleles and haplotypes are associated with an increased risk of developing paracoccidioidomycosis.
  • Ethnic variability is important in the HLA-paracoccidioidomycosis association.

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