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Malaria

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

Antiprotozoal Agents

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

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Related Experiment Video

Updated: Jul 2, 2026

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases

Published on: November 22, 2024

Control to elimination: implications for malaria research.

Brian M Greenwood¹

¹Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7 HT, UK. brian.greenwood@lshtm.ac.uk

Trends in Parasitology

|September 2, 2008

Summary

This summary is machine-generated.

Scaling up existing malaria control tools can achieve high control levels, renewing interest in malaria elimination. New research priorities include transmission-blocking drugs and vaccines, alongside novel surveillance to prevent reintroduction.

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Last Updated: Jul 2, 2026

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Published on: May 30, 2019

Area of Science:

Global Health
Infectious Diseases
Parasitology

Background:

Recent advancements demonstrate high malaria control is achievable with scaled-up existing interventions.
This success has revitalized discussions and support for malaria elimination strategies among major organizations.

Purpose of the Study:

To review research priorities in light of the renewed focus on malaria elimination.
To highlight the critical need for novel tools and strategies to support global malaria eradication efforts.

Main Methods:

Literature review and synthesis of recent reports on malaria control.
Analysis of current trends and future requirements for malaria elimination research.

Main Results:

Existing malaria control tools, when fully implemented, can lead to significant reductions in disease burden.
A shift in research focus towards transmission-blocking interventions and enhanced surveillance is indicated.

Conclusions:

Malaria elimination is a feasible goal with current tools, necessitating a strategic reprioritization of research and development.
Investment in transmission-blocking drugs, vaccines, and innovative surveillance systems is crucial for achieving and sustaining malaria-free regions.