Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

Huntington Disease l: Introduction

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Postmortem MRI reveals distinct structural features in sudden unexpected death in epilepsy.

Epilepsia open·2026

Same author

Tau pathology in epilepsy: emerging mechanisms and translational opportunities.

Brain : a journal of neurology·2026

Same author

Adult Medulloblastoma Presenting With Audiovestibular Symptoms and an Alternating Unterberger Test.

Cureus·2025

Same author

Primary spinal extradural cavernous haemangiomas: a report of three cases and review of literature.

British journal of neurosurgery·2025

Same author

Patterns of phosphorylated tau accumulation in a spectrum of acquired and developmental brain lesions associated with refractory epilepsy.

Epilepsia·2025

Same author

Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes.

Nature genetics·2025

Same journal

Non-Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions.

Brain pathology (Zurich, Switzerland)·2026

Same journal

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus.

Brain pathology (Zurich, Switzerland)·2026

Same journal

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies.

Brain pathology (Zurich, Switzerland)·2026

Same journal

A 3-year-old girl with a left optic nerve tumor.

Brain pathology (Zurich, Switzerland)·2026

Same journal

Chromosomal and immune dysregulation underlying granular mitosis in glioblastoma.

Brain pathology (Zurich, Switzerland)·2026

Same journal

Nearest-neighbors assisted unsupervised analysis for methylation array profiling for central nervous system tumors.

Brain pathology (Zurich, Switzerland)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Hippocampal sclerosis: progress since Sommer.

¹University College London, Institute of Neurology, Division of Neuropathology, London, UK. m.thom@ion.ucl.ac.uk

Brain Pathology (Zurich, Switzerland)

|September 3, 2008

Summary

This summary is machine-generated.

Hippocampal sclerosis (HS), a common finding in epilepsy surgery, involves neuronal loss in the hippocampus. Modern research explores its mechanisms, linking early injury to seizures and cellular changes.

More Related Videos

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Related Experiment Videos

Last Updated: Jul 2, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Area of Science:

Neuropathology
Epilepsy Research
Neuroscience

Background:

Hippocampal sclerosis (HS) is the primary pathology in refractory temporal lobe epilepsy surgery.
First described by Wilhelm Sommer over 120 years ago, HS involves characteristic neuronal loss.
Post-mortem and surgical specimen studies have elucidated HS patterns and limbic system involvement.

Discussion:

Early cerebral injury is recognized as a potential precipitant for HS and subsequent epilepsy.
Modern studies investigate neuronal injury, selective neuronal group loss, and cellular reorganization.
Research focuses on epileptogenesis mechanisms and the dual role of hippocampal vulnerability and glial proliferation in seizures.

Key Insights:

HS is a significant neuropathological finding in epilepsy.
Understanding HS mechanisms is crucial for treating refractory epilepsy.
Cellular changes in the hippocampus are central to seizure development.

Outlook:

Further research into neuronal vulnerability and glial roles may reveal new therapeutic targets.
Investigating the link between early injury and HS could inform preventative strategies.
Continued neuropathological analysis will refine our understanding of epilepsy progression.