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Updated: Jul 2, 2026
04:37
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
[Hypertension--does it matter how blood pressure is lowered?]
1Frederiksberg Hospital, Klinisk Fysiologisk/nuklearmedicinsk Afdeling, Frederiksberg. j_mehlsen@mac.com
Ugeskrift for Laeger
|September 3, 2008
Summary
The ASCOT study found that amlodipine-based blood pressure treatment and atorvastatin significantly reduced cardiovascular events. Effective blood pressure management is crucial for preventing heart issues.
Area of Science:
- Cardiology
- Pharmacology
- Public Health
Background:
- Hypertension and high cholesterol are major risk factors for cardiovascular disease (CVD).
- Optimal treatment strategies for managing hypertension and preventing CVD are continuously investigated.
Purpose of the Study:
- To compare the efficacy of two different antihypertensive drug combinations in hypertensive patients.
- To evaluate the effect of atorvastatin on cardiovascular events in patients with normal cholesterol levels.
Main Methods:
- The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) compared atenolol plus a thiazide diuretic against amlodipine plus perindopril.
- A substudy assessed the impact of atorvastatin on cardiovascular events in participants with normal cholesterol.
Main Results:
- Amlodipine-based treatment significantly reduced cardiovascular events compared to atenolol-based treatment, likely due to better central blood pressure control.
- Atorvastatin also demonstrated significant reductions in cardiovascular events.
- Both amlodipine-based and atorvastatin treatments were found to be cost-effective.
Conclusions:
- The choice of antihypertensive medication impacts cardiovascular event rates.
- Aggressive lipid-lowering therapy with atorvastatin is beneficial for cardiovascular event reduction, even in patients with normal cholesterol.
- Effective blood pressure control, particularly central blood pressure, is key in preventing cardiovascular events.
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