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Published on: February 27, 2026
Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication
Chung-Jen Chen1, Martin Michaelis, Hseng-Kuang Hsu
1Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan. chungjen@adm.cgmh.org.tw
Traditional Chinese medicine (TCM) research identified Toona sinensis Roem leaf extract as a potential antiviral agent against SARS-CoV. This vegetable extract shows promising in vitro efficacy for developing new SARS-CoV drugs.
Area of Science:
- Pharmacology
- Virology
- Ethnobotany
Background:
- Severe acute respiratory syndrome (SARS) is a critical illness caused by the SARS coronavirus (SARS-CoV).
- Developing novel antiviral therapies for SARS-CoV remains a significant public health concern.
- Traditional Chinese Medicine (TCM) offers a rich source for identifying new therapeutic agents.
Purpose of the Study:
- To explore potential antiviral resources from TCM for combating SARS-CoV.
- To investigate the efficacy of selected TCM formulae, herbs, and plant extracts against SARS-CoV in vitro.
Main Methods:
- Recruited TCM formulae from classical texts (Shang-Han Lun, Wen-Bing Tiau-Bein).
- Included herbs recommended by TCM experts for SARS treatment.
- Tested an extract from the tender leaf of Toona sinensis Roem (Cedrela sinensis) for in vitro activity against SARS-CoV.
Main Results:
- The extract from the tender leaf of Toona sinensis Roem (TSL-1) demonstrated significant antiviral activity against SARS-CoV.
- TSL-1 exhibited a selectivity index of approximately 12-17, indicating a favorable therapeutic window.
Conclusions:
- This study is the first to report the in vitro inhibitory effect of Toona sinensis Roem leaf extract on SARS-CoV.
- The tender leaf of Toona sinensis Roem represents a promising natural resource for the development of novel anti-SARS-CoV therapeutics.
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