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Related Concept Videos

Cellular Adaptation III: Hyperplasia01:26

Cellular Adaptation III: Hyperplasia

Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...
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Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Testosterone: Functions and Regulation

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Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
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Updated: Jul 2, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Growth factors in benign prostatic hyperplasia: basic science implications.

M Scott Lucia1, James R Lambert

  • 1Department of Pathology, University of Colorado DHSC, 12800 East 19th Avenue, PO Box 6511, Aurora, CO 80045, USA. scott.lucia@uchsc.edu

Current Urology Reports
|September 4, 2008
PubMed
Summary
This summary is machine-generated.

Benign prostatic hyperplasia (BPH) involves complex growth factors and inflammation. Understanding these pathways may lead to new BPH treatments targeting prostate cell growth.

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Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
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Last Updated: Jul 2, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

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Published on: August 14, 2019

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
08:38

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

Published on: August 28, 2013

Area of Science:

  • Urology
  • Pathology
  • Molecular Biology

Background:

  • Benign prostatic hyperplasia (BPH) is a prevalent prostate condition in aging men.
  • BPH pathogenesis involves complex interactions of local growth factors and inflammatory cytokines.
  • Key molecular players include fibroblast growth factors, insulin-like growth factors, and transforming growth factors.

Purpose of the Study:

  • To elucidate the molecular mechanisms driving benign prostatic hyperplasia (BPH) progression.
  • To investigate the role of growth factors and inflammatory cytokines in BPH pathogenesis.
  • To identify potential therapeutic targets within the signaling pathways implicated in BPH.

Main Methods:

  • Histopathological analysis of prostate tissue.
  • Molecular profiling to assess protein and cytokine expression.
  • Examination of signaling pathways involved in cell growth and angiogenesis.

Main Results:

  • Overexpression of specific growth factors (fibroblast, insulin-like, transforming) and interleukins in BPH tissues.
  • Evidence of increased stromal and epithelial cell proliferation.
  • Association between inflammation, angiogenesis, and disease progression in BPH.

Conclusions:

  • Local growth factors and inflammatory cytokines are critical drivers of BPH.
  • Inflammation may trigger a wound-healing response, promoting prostate growth and angiogenesis.
  • Targeting these interacting pathways offers a promising strategy for novel BPH therapies.