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Updated: Jun 29, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Symptom clusters related to treatment for prostate cancer
Sally L Maliski1, Lorna Kwan, David Elashoff
1School of Nursing, University of California, Los Angeles, USA. smaliski@sonnet.ucla.edu
Purpose/Objectives:
To identify symptom clusters that include urinary and erectile dysfunction among men treated for prostate cancer.
Design:
Secondary data analysis.
Setting:
University-affiliated urology clinic.
Sample:
Data collected on 402 men for a longitudinal prostate cancer quality-of-life study.
Methods:
Data were collected from an eight-month time point. Four analytic approaches were applied to determine whether consistent clusters of symptoms were identifiable.
Main Research Variables:
Pain, fatigue, emotional distress, and urinary, sexual, and bowel dysfunction.
Findings:
Thirty-three percent of patients reported scores on three or more quality-of-life measures falling in the lowest quartile for that measure. Although composition of the clusters was not consistent, poor mental health or poor energy was a component of any cluster made up of three or more symptoms.
Conclusions:
Using a four-way analytic approach enabled the authors to explore how symptom clusters measuring general and disease-specific quality of life occurred in patients who have been treated for prostate cancer. When clusters occur, fatigue and emotional distress often are included.
Implications For Nursing:
Fatigue and emotional distress may be seen together or in combination with prostate cancer-specific symptoms. Nurses should be more alert to the possibility of additional treatment-related symptoms when fatigue or emotional distress is present.
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