Has UK guidance affected general practitioner antibiotic prescribing for otitis media in children?

P L Thompson1, R E Gilbert, P F Long

  • 1Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London, BMA House, Tavistock Square, London, UK.

Insights

Antibiotic prescribing for otitis media decreased before UK guidance, with a shift from non-acute to acute diagnoses. This suggests diagnostic changes, not guidance, influenced prescribing trends.

Area of Science:

  • Pediatrics
  • General Practice
  • Pharmacology

Background:

  • UK guidance since 1997 recommended limiting antibiotic prescribing for otitis media.
  • The impact of this guidance on general practitioner prescribing practices was unknown.

Purpose of the Study:

  • To investigate trends in otitis media diagnoses and antibiotic prescribing in children.
  • To analyze these trends in relation to UK guidance.

Main Methods:

  • Time-trend analyses of diagnoses and antibiotic prescribing for otitis media.
  • Utilized the General Practice Research Database for children aged 3 months to 15 years (1990-2006).

Main Results:

  • Over 1.2 million otitis media episodes were analyzed; 68% received antibiotics.
  • Antibiotic prescribing for otitis media declined by 51% between 1995-2000, predating guidance.
  • Prescribing for acute otitis media increased by 22% during this period, with diagnoses paralleling prescribing.

Conclusions:

  • The observed reduction in antibiotic prescribing for otitis media preceded official guidance.
  • A shift in coding from non-acute to acute otitis media suggests diagnostic transfer may have influenced prescribing decisions.
Abstract

Related Concept Videos

Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...