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Development and Application of Rapamycin-regulated Tyrosine Phosphatases
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E-cadherin dis-engagement activates the Rap1 GTPase

Sirisha Asuri1, Jingliang Yan, Nivanka C Paranavitana

  • 1Department of Biochemistry and Molecular Biology, Indiana University School of Medicine and Walther Oncology Center, Indianapolis, Indiana 46202, USA.

Journal of Cellular Biochemistry
|September 4, 2008
PubMed
Summary

The Ras-related Rap1 GTPase strengthens E-cadherin junctions, aiding cell-cell contact maintenance and repair. It is activated by E-cadherin engagement through signaling pathways involving PDZ-GEF I.

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