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Related Concept Videos

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
Drug Nomenclature01:17

Drug Nomenclature

During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that the same...

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[Off-label prescribing].

Katherine Blondon1, Jules Desmeules, Nicole Vogt-Ferrier

  • 1Service de médecine interne générale, HUG, 1211 Genève 14. katherine.blondon@hcuge.ch

Revue Medicale Suisse
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Summary
This summary is machine-generated.

Off-label prescribing, using medications for unapproved conditions, is common in medicine. It requires strong evidence and informed consent, as physicians bear responsibility for potential risks and insurance coverage is not guaranteed.

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Area of Science:

  • Pharmacology
  • Medical Ethics
  • Regulatory Affairs

Context:

  • Off-label prescribing involves using medications for conditions not approved by regulatory bodies like Swissmedic.
  • This practice is prevalent across medical fields and may be the sole therapeutic option for rare diseases or specific patient groups.

Purpose:

  • To define and contextualize off-label prescribing within the Swiss regulatory framework.
  • To highlight the importance of scientific evidence, patient information, and physician responsibility in off-label drug use.

Summary:

  • Off-label drug use is common and may offer the only treatment for certain conditions or populations.
  • It necessitates a basis in sound scientific evidence of efficacy and safety.
  • Patients must be informed about potential lack of health insurance coverage in Switzerland.

Impact:

  • Physicians prescribing off-label assume responsibility for potential risks and legal implications.
  • This practice underscores the need for clear guidelines and ethical considerations in drug utilization.
  • Ensuring patient safety and informed consent is paramount in off-label prescribing scenarios.