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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
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A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

Vesicular trafficking in osteoclasts.

Fraser P Coxon1, Adam Taylor

  • 1Bone & Musculoskeletal Programme, School of Medicine & Dentistry, Institute of Medical Sciences, University of Aberdeen, Foresterhill, UK. f.p.coxon@abdn.ac.uk

Seminars in Cell & Developmental Biology
|September 5, 2008
PubMed
Summary
This summary is machine-generated.

Osteoclasts rely on vesicular transport for bone resorption. Defects in these pathways, regulated by Rab GTPases, are linked to osteopetrosis, a bone disease.

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Last Updated: Jul 2, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

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Published on: June 16, 2022

Osteoclast Derivation from Mouse Bone Marrow
06:17

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Published on: November 6, 2014

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow
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Published on: May 19, 2019

Area of Science:

  • Cell Biology
  • Bone Biology
  • Molecular Biology

Background:

  • Osteoclasts are crucial for bone remodeling.
  • Vesicular trafficking pathways, regulated by Rab GTPases, are essential for osteoclast function.
  • Polarized transport of acidic vesicles forms the osteoclast's ruffled border for bone resorption.

Purpose of the Study:

  • To review vesicular trafficking routes in osteoclasts.
  • To highlight the role of vesicular trafficking defects in osteopetrosis.
  • To compare osteoclast endocytic/lysosomal compartments with secretory lysosomes.

Main Methods:

  • Literature review of vesicular trafficking in osteoclasts.
  • Analysis of Rab GTPase regulation in osteoclast function.
  • Comparison of osteoclast and secretory lysosome pathways.

Main Results:

  • Osteoclast function, including ruffled border formation and resorption product transport, is dependent on endocytic/lysosomal pathways.
  • Defects in these vesicular trafficking routes are implicated in osteopetrosis.
  • Similarities exist between osteoclast endocytic/lysosomal compartments and secretory lysosomes.

Conclusions:

  • Vesicular trafficking is critical for osteoclast-mediated bone resorption.
  • Disruptions in osteoclast vesicular transport contribute to bone diseases like osteopetrosis.
  • Osteoclasts share functional similarities with other secretory lysosome-containing cells.