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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Cross-reactivity00:42

Cross-reactivity

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Related Experiment Video

Updated: Jul 2, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses
08:28

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

Contact lenses and allergy.

Michael A Lemp1

  • 1Department of Ophthalmology, Georgetown University, George Washington University, Washington, District of Columbia, USA. malemp@lempdc.com

Current Opinion in Allergy and Clinical Immunology
|September 5, 2008
PubMed
Summary

Contact lens wear can impact ocular allergy. This review explores how allergies affect contact lens wear and how lenses can manage severe allergic eye disease.

Area of Science:

  • Ophthalmology
  • Allergy and Immunology
  • Biomaterials Science

Background:

  • Ocular allergy and contact lens wear are prevalent conditions affecting many individuals.
  • The interaction between allergic eye disease and contact lens wear presents significant clinical challenges.
  • Contact lenses are increasingly utilized in managing severe ocular allergic conditions.

Purpose of the Study:

  • To review the effects of contact lens wear on tear film dynamics and structure.
  • To examine the impact of ocular allergy on tear dynamics and structure.
  • To explore the intersection of contact lens wear and ocular allergy, including management strategies and therapeutic applications of contact lenses.

Main Methods:

  • Comprehensive literature review focusing on the interplay between ocular allergy and contact lens wear.

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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

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Related Experiment Videos

Last Updated: Jul 2, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses
08:28

Development of an In Vitro Ocular Platform to Test Contact Lenses

Published on: April 6, 2016

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

  • Analysis of studies investigating tear film alterations in response to contact lens use and allergic conditions.
  • Evaluation of current and emerging management strategies for contact lens wearers with ocular allergies.

    • Main Results:

    • Contact lens wear significantly alters tear film dynamics and structure.
    • Ocular allergy profoundly affects tear film composition and stability.
    • The combination of contact lens wear and ocular allergy exacerbates ocular surface changes, necessitating tailored management approaches.

    Conclusions:

    • Newer oral and topical antiallergic medications offer improved management options for contact lens wearers.
    • Updated recommendations for contact lens use and wearing schedules are crucial for allergic patients.
    • Scleral lenses show promise in managing severe allergic ocular surface disease.