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Updated: Jul 2, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

[Resistant hypertension].

Carlos A Feldstein¹

¹Programa Hipertensión Arterial, Hospital de Clínicas José de San Martín, UBA, Buenos Aires, Argentina. carlfel@yahoo.com

Revista Medica De Chile

|September 5, 2008

Summary

Resistant hypertension, a blood pressure over 140/90 mmHg despite three medications, requires careful diagnosis. Aldosterone antagonists show promise as a fourth-line treatment for this condition.

Area of Science:

Cardiology
Nephrology
Pharmacology

Context:

Resistant hypertension is defined as persistent high blood pressure (over 140/90 mmHg) despite a three-drug regimen including a diuretic.
Accurate diagnosis involves excluding pseudoresistance, non-compliance, and white coat hypertension via ambulatory blood pressure monitoring.
Secondary causes and contributing factors like excessive salt intake, obesity, diabetes, chronic kidney disease, and psychiatric conditions must be investigated.

Purpose:

To outline the diagnostic challenges and management strategies for resistant hypertension.
To highlight the role of secondary causes and target organ damage in treatment decisions.
To review emerging therapeutic options for difficult-to-control hypertension.

Summary:

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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

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Last Updated: Jul 2, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Resistant hypertension necessitates ruling out pseudoresistance and non-compliance, with ambulatory monitoring aiding diagnosis.

Secondary causes, lifestyle factors, and target organ damage are critical considerations for effective management.

Aldosterone antagonists are a promising fourth-line therapy, offering significant blood pressure reduction in resistant cases.

Investigational therapies, such as carotid baroreceptor electrical activation, are being explored for future treatment.

Impact:

Improved diagnostic accuracy for resistant hypertension.
Enhanced treatment strategies for patients with uncontrolled high blood pressure.
Potential for new therapeutic interventions to manage resistant hypertension effectively.