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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
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Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
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Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
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Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
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Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

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Published on: January 18, 2018

Therapeutic strategy for ischemic stroke.

Toru Yamashita1, Kentaro Deguchi, Yoshihide Sehara

  • 1Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8558, Japan. tooy@d1.dion.ne.jp

Neurochemical Research
|September 5, 2008
PubMed
Summary

This study explores neuroprotection and stem cell therapy for ischemic stroke. Azelnidipine, biliverdin, and G-CSF showed neuroprotective effects, while a bio-affinitive scaffold aids neuronal repair.

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Pharmacology

Background:

  • Ischemic stroke causes neuronal damage and network disruption.
  • Current treatments focus on acute neuroprotection and chronic repair strategies.

Purpose of the Study:

  • To evaluate neuroprotective agents like azelnidipine and biliverdin.
  • To investigate the role of granulocyte colony-stimulating factor (G-CSF) in neuroprotection.
  • To develop a scaffold-based therapy for neuronal network restoration.

Main Methods:

  • Assessed neuroprotective effects of azelnidipine and biliverdin in ischemic brains.
  • Administered G-CSF to rats post-cerebral ischemia.
  • Developed a bio-affinitive scaffold for neural regeneration.

Main Results:

  • Aznidipine and biliverdin demonstrated neuroprotection via anti-oxidative properties.
  • G-CSF plays a critical role in neuroprotection following cerebral ischemia.
  • The developed scaffold supports the environment for newly born neurons.

Conclusions:

  • Azelnidipine, biliverdin, and G-CSF are potential neuroprotective agents for ischemic stroke.
  • Scaffold-based therapy shows promise for repairing neuronal networks.
  • Combining neuroprotection and regenerative strategies may lead to more effective stroke treatments.