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Updated: Jul 2, 2026
An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses
Published on: July 7, 2017
Interleukin-10 is an essential modulator of mucoid metaplasia in a mouse otitis media model
Katsuyuki Tsuchiya1, Masahiro Komori, Qing Yin Zheng
1University of Minnesota Otitis Media Research Center, Department of Otolaryngology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Objectives:
Inflammatory cytokines are involved in the development of mucous cell metaplasia and hyperplasia (MCM) in otitis media (OM). However, which cytokines play an essential role in the MCM of OM is not clear at the moment.
Methods:
In this study, we hypothesized that interleukin-10 (IL-10) played an indispensable role in the MCM of bacterial OM, and we used IL-10 knockout mice to test this hypothesis.
Results:
In wild-type mice, both Streptococcus pneumoniae and Haemophilus influenzae triggered the development of MCM in the middle ear mucosa. In IL-10 knockout mice, the number of goblet cells and mucin-producing cells in the middle ear was significantly reduced after bacterial middle ear infection compared with that in wild-type mice.
Conclusions:
We conclude that IL-10 plays an essential role in the MCM of bacterial OM. Interleukin-10 is a potential target for the treatment of MCM in OM.
