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Updated: Jul 2, 2026

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
Published on: November 17, 2011
1,3-Diaxially substituted trans-decalins: potential nonsteroidal human progesterone receptor inhibitors
Ze Li1, E Blake Watkins, Hua Liu
1Department of Medicinal Chemistry, The University of Mississippi, P.O. Box 1848, University, Mississippi 38677, USA.
Abstract:
On the basis of molecular modeling and QSAR analysis of the known human progesterone receptor (hPR) inhibitor Mifepristone (RU-486) and other hPR ligands, a new class of potential nonsteroidal hPR inhibitors was designed. The parent racemic compound 1 was synthesized through an efficient 13-step synthetic pathway. The key constructive steps are a stereoselective epoxide ring opening and the reductive Heck cyclization to form the main framework of (+/-)-1. The current established flexible synthetic route allows for further chemical diversification.
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