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A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
Bleeding into the intraluminal thrombus in abdominal aortic aneurysms is associated with rupture
Joy Roy1, Fausto Labruto, Mats O Beckman
1Department of Surgery, Capio St. Görans Hospital, Stockholm, Sweden. joy.roy@ki.se
Insights
Multislice computed tomography (CT) can identify bleeding signs within abdominal aortic aneurysm (AAA) thrombus, like the crescent sign. Higher thrombus attenuation on CT is associated with AAA rupture.
Area of Science:
- Radiology
- Vascular Surgery
- Medical Imaging
Background:
- Abdominal aortic aneurysms (AAA) pose significant rupture risk.
- Early detection of AAA rupture is critical for patient outcomes.
- Identifying bleeding within the aneurysm thrombus may indicate impending rupture.
Purpose of the Study:
- To evaluate multislice computed tomography (CT) for detecting signs of bleeding in the intraluminal thrombus of abdominal aortic aneurysms (AAA).
- To determine the utility of CT in localizing the rupture site in patients with ruptured AAA.
- To correlate CT findings with the presence and location of AAA rupture.
Main Methods:
- Analysis of CT images from 42 patients with ruptured infrarenal AAA and 36 control patients with intact AAA.
- Interpretation of "crescent sign" and localized hyperattenuation in thrombus as indicators of bleeding.
- Quantification of thrombus attenuation using CT software (Hounsfield units).
Main Results:
- The "crescent sign" was significantly more frequent in ruptured AAA (38% vs. 14%, P = .02).
- Thrombus attenuation was significantly higher in ruptured AAA compared to intact AAA (P = .02).
- The rupture site was identified in 29/42 patients, commonly on the left lateral wall (45%).
Conclusions:
- Multislice CT can identify the rupture site in a majority of AAA cases.
- Higher thrombus attenuation and the "crescent sign" are associated with AAA rupture.
- Further research is needed to establish if these CT findings predict AAA rupture.
Objective:
The aim of this study was to determine signs of bleeding in the intraluminal thrombus and the site of rupture using multislice computed tomography (CT) imaging in patients with abdominal aortic aneurysms (AAA).
Methods:
We analyzed CT images of 42 patients with ruptured infrarenal AAA in two hospitals in Stockholm, Sweden during a 3-year period. A "crescent sign" or localized areas with higher attenuation in the thrombus were interpreted as signs of bleeding in the thrombus. A localized area of hyperattenuation did not have the typical crescent shape and was distinguished from calcifications in the thrombus. We measured the attenuation in Hounsfield units in the intraluminal thrombus using CT software to quantify the presence of blood in the thrombus. As controls, we analyzed 36 patients with intact AAA and a comparable aneurysm diameter and age.
Results:
The crescent sign was more frequent in the ruptured group (38% vs 14%, P = .02), but there was no significant difference in the presence of localized areas of hyperattenuation in the two groups. The attenuation in the thrombus was significantly higher in patients with rupture than in those with intact aneurysms (P = .02). The site of rupture could be localized in 29/42 patients. Ruptures occurred both through the thrombus-covered and the thrombus free wall. In 45% of the patients, the rupture site was localized in the left lateral wall, in 24% in the anterior wall, in 24% in the right lateral wall, but only in 7% in the posterior wall.
Conclusion:
The site of rupture could be identified in a majority of cases of AAA with routine multislice CT. This study demonstrates an association between the presence of blood in the thrombus as suggested by higher attenuation levels and a crescent sign and AAA rupture. If these findings also predict AAA rupture, remains to be established.
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