Related Experiment Videos

Management of osteoporosis in children

Nicholas J Shaw1

  • 1Department of Endocrinology, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B46NH, UK. nick.shaw@bch.nhs.uk

Insights

Pediatric osteoporosis is rising due to complex chronic conditions and improved care. This review covers its definition, causes, and effective treatments for children.

Area of Science:

  • Pediatric Endocrinology
  • Bone Metabolism
  • Child Health

Background:

  • Osteoporosis is increasingly recognized in pediatric practice.
  • Complex chronic conditions and their treatments contribute to pediatric osteoporosis.
  • Improved pediatric care allows children to live longer, increasing osteoporosis risk.

Purpose of the Study:

  • To review the current definition of osteoporosis in children.
  • To explore the etiological factors contributing to pediatric osteoporosis.
  • To examine the evidence for effective treatments for pediatric osteoporosis.

Main Methods:

  • Literature review of osteoporosis in children.
  • Analysis of current diagnostic criteria and risk factors.
  • Evaluation of treatment efficacy for pediatric bone density enhancement.

Main Results:

  • Growing awareness of pediatric osteoporosis due to increased survival rates of children with chronic illnesses.
  • Bone density assessment methods are available for children.
  • Medical treatments to increase bone density are being explored.

Conclusions:

  • Osteoporosis is a significant concern in pediatric practice.
  • Understanding the definition, causes, and treatments is crucial for managing pediatric osteoporosis.
  • Further research into effective treatments is warranted.

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...