Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atomic Force Microscopy01:08

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
High-Resolution Mass Spectrometry (HRMS)01:15

High-Resolution Mass Spectrometry (HRMS)

The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the sum of the masses of protons and neutrons inside, considering the masses of protons and neutrons as equal. However, the masses of the proton (1.6726 × 10−24 g) and neutron (1.6749 × 10−24 g) are not truly equal. There is a minor error in the expression of atomic masses relative to the simplest atom of hydrogen. For example, the mass of helium...
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sweat Gland Carcinoma of the Lower Eyelid.

Deutsches Arzteblatt international·2026
Same author

High-throughput sequencing of nodal marginal zone lymphomas identifies recurrent BRAF mutations.

Leukemia·2018
Same author

Bothersome Cutaneous Lesion for more than 30 Years: Dilated Pore of Winer.

Klinische Monatsblatter fur Augenheilkunde·2017
Same author

Ultraconfined Plasmonic Hotspots Inside Graphene Nanobubbles.

Nano letters·2016
Same author

Isolated tumor cells in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival.

BMC cancer·2016
Same author

Nanoparticle imaging. 3D structure of individual nanocrystals in solution by electron microscopy.

Science (New York, N.Y.)·2015
Same journal

Halide-site-substituting spacer creates quasi-two-dimensional perovskites for vapour-deposited light-emitting diodes.

Nature nanotechnology·2026
Same journal

Nanoscale amorphization of poly(triarylamine) for efficient and stable inverted perovskite photovoltaics.

Nature nanotechnology·2026
Same journal

Bridging nanotechnology and mechanobiology.

Nature nanotechnology·2026
Same journal

Coherent 2D/3D van der Waals epitaxy enables single-crystal perovskite heterostructures.

Nature nanotechnology·2026
Same journal

Coherent 2D-3D van der Waals perovskite epitaxial heterostructures.

Nature nanotechnology·2026
Same journal

Ultrafast, reconfigurable all-optical beam steering and spatial light modulation.

Nature nanotechnology·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2026

Atomic Force Microscopy Cantilever-Based Nanoindentation: Mechanical Property Measurements at the Nanoscale in Air and Fluid
08:58

Atomic Force Microscopy Cantilever-Based Nanoindentation: Mechanical Property Measurements at the Nanoscale in Air and Fluid

Published on: December 2, 2022

An atomic-resolution nanomechanical mass sensor.

K Jensen, Kwanpyo Kim, A Zettl

    Nature Nanotechnology
    |September 6, 2008
    PubMed
    Summary
    This summary is machine-generated.

    Researchers developed a carbon-nanotube nanomechanical resonator capable of detecting single atoms. This room-temperature device achieves atomic mass resolution, functioning as a highly sensitive mass spectrometer without sample ionization.

    More Related Videos

    Picometer-Precision Atomic Position Tracking through Electron Microscopy
    15:04

    Picometer-Precision Atomic Position Tracking through Electron Microscopy

    Published on: July 3, 2021

    Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid
    10:25

    Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid

    Published on: December 20, 2016

    Related Experiment Videos

    Last Updated: Jul 2, 2026

    Atomic Force Microscopy Cantilever-Based Nanoindentation: Mechanical Property Measurements at the Nanoscale in Air and Fluid
    08:58

    Atomic Force Microscopy Cantilever-Based Nanoindentation: Mechanical Property Measurements at the Nanoscale in Air and Fluid

    Published on: December 2, 2022

    Picometer-Precision Atomic Position Tracking through Electron Microscopy
    15:04

    Picometer-Precision Atomic Position Tracking through Electron Microscopy

    Published on: July 3, 2021

    Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid
    10:25

    Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid

    Published on: December 20, 2016

    Area of Science:

    • Physics
    • Materials Science
    • Nanotechnology

    Background:

    • Mechanical resonators are crucial for detecting minute mass changes via frequency shifts.
    • Nanoscale resonators fabricated using advanced techniques serve as precision sensors.
    • Carbon-nanotube-based resonators offer unique properties for sensitive measurements.

    Discussion:

    • Demonstration of a room-temperature, carbon-nanotube nanomechanical resonator.
    • Achieved atomic mass resolution with a mass sensitivity of 1.3 x 10(-25) kg Hz(-1/2).
    • Observed atomic mass shot noise, analogous to electronic shot noise in semiconductors.

    Key Insights:

    • The nanomechanical resonator functions as a mass spectrometer with unprecedented sensitivity.
    • This technology bypasses the need for sample ionization, unlike traditional mass spectrometers.
    • The device exhibits enhanced sensitivity for larger molecules.

    Outlook:

    • Potential for chip-scale integration of nanomechanical mass spectrometers.
    • Further development could lead to non-destructive analysis of atomic and molecular masses.
    • Opens new avenues for precision sensing in various scientific and technological fields.