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Generation of Local CA1 γ Oscillations by Tetanic Stimulation
Published on: August 14, 2015
Rhythm generation through period concatenation in rat somatosensory cortex
Mark A Kramer1, Anita K Roopun, Lucy M Carracedo
1Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, United States of America. mak@bu.edu
Plos Computational Biology
|September 6, 2008
Summary
Neuronal oscillations in rat somatosensory cortex can combine through period concatenation, switching from faster gamma and beta2 rhythms to a slower beta1 rhythm. This switch involves dynamic motifs and strengthened connections in deep cortical layers.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Systems Neuroscience
Background:
- Neuronal populations generate rhythmic voltage oscillations.
- Interactions and dominance switching between coexistent oscillations are observed.
- Previous work identified a transition from gamma and beta2 rhythms to a beta1 rhythm in rat somatosensory cortex.
Purpose of the Study:
- Investigate the fundamental mechanisms underlying the beta1 rhythm.
- Explore the period concatenation hypothesis for rhythm switching.
- Identify components that promote or inhibit specific rhythms.
Main Methods:
- In vitro electrophysiological recordings from rat somatosensory cortex.
- Development of a simplified, biologically realistic computational model.
- Analysis of neural activity and rhythmic oscillations.
Main Results:
- Observed a transition from coexistent gamma (25 ms) and beta2 (40 ms) rhythms to a synchronous beta1 (65 ms) rhythm.
- Period concatenation (25 ms + 40 ms = 65 ms) proposed as the mechanism for the switch.
- Model suggests dynamic motifs of gamma and beta2 rhythms combine to form beta1, exhibiting cross-frequency interactions.
Conclusions:
- The beta1 oscillation arises from the combination of faster gamma and beta2 rhythms via period concatenation.
- Strengthened connections between deep layer intrinsically bursting cells and altered spike generation are vital for beta1 rhythm.
- Neural activity in superficial and deep cortical layers temporally combines to generate slower oscillations.
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