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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

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Updated: Jul 2, 2026

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells
08:00

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

Published on: January 12, 2015

[Heart tissue from embryonic stem cells].

W-H Zimmermann1

  • 1Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, BRD. w.zimmermann@uke.uni-hamburg.de

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
|September 6, 2008
PubMed
Summary
This summary is machine-generated.

Embryonic stem cells offer potential for engineering human heart muscle. This research explores their use in tissue engineering for drug screening and repairing heart damage.

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Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

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Last Updated: Jul 2, 2026

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells
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Published on: January 12, 2015

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
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Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

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Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Biomedical Engineering

Context:

  • Embryonic stem cells (ESCs) possess pluripotency, enabling differentiation into all somatic cell types.
  • The intrinsic ability of cells to form tissue-like structures in vitro is a key principle in tissue engineering.
  • Previous studies demonstrated the feasibility of engineering force-generating heart muscle using immature cells from various species.

Purpose:

  • To review the application of stem cells for generating human heart muscle.
  • To outline the potential of engineered myocardium for in vitro disease modeling and drug development.
  • To discuss the therapeutic applications of engineered cardiac tissue for myocardial repair.

Summary:

  • This overview examines the use of embryonic and non-embryonic stem cells in myocardial tissue engineering.
  • It details the progression from early proof-of-concept studies to current goals focused on human applications.
  • The potential direct and indirect therapeutic benefits of human tissue-engineered myocardium are explored.

Impact:

  • Enables the development of advanced in vitro models for studying heart muscle development and disease.
  • Provides a human-specific platform for preclinical drug screening and efficacy testing.
  • Offers a promising avenue for generating surrogate cardiac tissue for regenerative medicine and myocardial repair applications.