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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

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Updated: Jul 2, 2026

Culture and Maintenance of Human Embryonic Stem Cells

Culture and Maintenance of Human Embryonic Stem Cells

Published on: December 22, 2009

Human embryonic stem cell registries: value, challenges and opportunities.

Mai X Luong¹, Kelly P Smith, Gary S Stein

¹Department of Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. mai.luong@umassmed.edu

Journal of Cellular Biochemistry

|September 6, 2008

Summary

Developing human embryonic stem cell (hESC) registries is crucial for organizing research data. These registries face legal, ethical, and technical challenges, necessitating cooperative development to support the field effectively.

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Area of Science:

Biomedical research
Stem cell biology
Bioinformatics

Background:

Human embryonic stem cell (hESC) research is advancing rapidly.
There is a growing need for centralized information repositories (registries) for hESC data.
Existing challenges hinder the effective development and implementation of hESC registries.

Purpose of the Study:

To highlight the critical need for hESC registries.
To identify the significant challenges in developing and maintaining these registries.
To propose cooperative mechanisms for registry development.

Main Methods:

Literature review of current hESC research and registry initiatives.
Analysis of legal, ethical, and intellectual property issues related to hESC derivation.
Identification of technical requirements for data gathering, validation, and dissemination.

Main Results:

hESC registries are essential for managing the increasing volume of research data.
Key challenges include navigating legal/ethical complexities and intellectual property rights.
Efficient data management tools are required for diverse information types and sources.
Cooperative development is vital to prevent redundancy and maximize support for research.

Conclusions:

The development of robust hESC registries is imperative for the advancement of stem cell research.
Addressing legal, ethical, and technical hurdles through collaboration is essential for registry success.
Cooperative strategies will enhance data accessibility and accelerate scientific discovery in the hESC field.