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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...

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Related Experiment Videos

Aripiprazole-induced acneiform eruption.

Biswaranjan Mishra1, Samir Kumar Praharaj, Ravi Prakash

  • 1Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand 834006, India.

General Hospital Psychiatry
|September 9, 2008
PubMed
Summary
This summary is machine-generated.

Drug-induced acneiform eruptions, resembling acne vulgaris, can occur during aripiprazole treatment. Discontinuing the medication and using topical retinoic acid resolved the eruption, suggesting a possible allergic reaction.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Pharmacology
  • Immunology

Background:

  • Drug-induced acneiform eruptions are inflammatory follicular reactions mimicking acne vulgaris.
  • These eruptions present as papulopustules and sometimes comedones.
  • Understanding the mechanisms behind drug-induced skin reactions is crucial for patient management.

Observation:

  • A case report details a patient developing acneiform eruptions during aripiprazole therapy.
  • The eruption's morphology and distribution were consistent with acneiform eruptions.
  • Clinical observation noted the eruption's resolution upon medication cessation.

Findings:

  • Discontinuation of aripiprazole led to the resolution of the acneiform eruption.
  • Topical retinoic acid application further aided in clearing the skin condition.
  • The findings suggest a potential Type III allergic mechanism in a sensitized individual.

Implications:

  • This case highlights a potential adverse dermatological effect of aripiprazole.
  • It underscores the importance of considering drug-induced reactions in differential diagnosis.
  • The proposed allergic mechanism warrants further investigation in similar cases.