Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world evidence on infection risk in multiple myeloma treated with BiTEs and CAR-T cells: a meta-analysis.

Experimental hematology & oncology·2026
Same author

Eosinophil-linked pulmonary circulation in EGPA Improves under anti-IL-5/R therapy: A longitudinal study.

European journal of internal medicine·2026
Same author

What is your next step? A case of malabsorption with imitation game.

Internal and emergency medicine·2026
Same author

Inborn errors of immunity: a structured model for paediatric-to-adult transition of care.

Frontiers in immunology·2026
Same author

Navigating primary and secondary immunodeficiency intersections: how to find IEI hidden within SID.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology·2026
Same author

Efficacy of belimumab in patients with SLE and haematological manifestations: retrospective analysis from the BeRLiSS 2.0 cohort.

Lupus science & medicine·2026

Related Experiment Video

Updated: Jul 2, 2026

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software
07:32

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software

Published on: April 12, 2024

Tumoral mast cells exhibit a common spatial distribution.

Diego Guidolin1, Beatrice Nico, Enrico Crivellato

  • 1Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua Medical School, Padua, Italy.

Cancer Letters
|September 9, 2008
PubMed
Summary
This summary is machine-generated.

Mast cells (MCs) accumulate around tumors and influence inflammation. This study found MCs exhibit a random spatial distribution in various human tumors, suggesting limited cell-cell interaction in their pattern formation.

More Related Videos

Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
06:05

Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

Related Experiment Videos

Last Updated: Jul 2, 2026

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software
07:32

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software

Published on: April 12, 2024

Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment
06:05

Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment
11:00

Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment

Published on: March 25, 2020

Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Mast cells (MCs) are present in tumor stroma and contribute to inflammation.
  • MCs secrete pro-angiogenic factors and matrix metalloproteinases, influencing tumor microenvironment.
  • Understanding MC distribution is crucial for cancer research.

Purpose of the Study:

  • To quantitatively analyze the spatial distribution patterns of mast cells in diverse human tumor biopsy samples.
  • To investigate the potential role of cell-cell interactions in mast cell arrangement within neoplastic tissues.
  • To explore factors contributing to mast cell spatial distribution in tumors.

Main Methods:

  • Utilized an image analysis system for quantitative assessment of mast cell distribution.
  • Applied a mathematical model to characterize the spatial arrangement of mast cells.
  • Examined biopsy samples from four distinct human tumor types.

Main Results:

  • Mast cells showed a virtually random spatial distribution across all examined neoplastic tissues.
  • Despite histological variations, the spatial arrangement pattern of MCs was consistent.
  • Varying densities of mast cells were observed, but their arrangement remained random.

Conclusions:

  • Mast cell-mast cell interactions appear to play a minimal role in shaping MC patterns in tumors.
  • The random distribution may result from random walk migration influenced by cell-matrix interactions or chemotactic signals.
  • Tumor and endothelial cells might generate chemotactic fields influencing mast cell migration.