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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

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Related Experiment Video

Updated: Jul 1, 2026

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

Published on: January 12, 2015

Human embryonic stem cells for cardiomyogenesis.

Manhal Habib¹, Oren Caspi, Lior Gepstein

¹Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Journal of Molecular and Cellular Cardiology

|September 9, 2008

Summary

This summary is machine-generated.

Human embryonic stem cells (hESC) offer a promising source for cardiomyocytes in heart failure therapy. Research reviews hESC derivation, differentiation, and applications in cardiac repair and tissue engineering.

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Published on: November 3, 2011

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Last Updated: Jul 1, 2026

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

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Published on: January 12, 2015

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Efficient Derivation of Human Cardiac Precursors and Cardiomyocytes from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction

Efficient Derivation of Human Cardiac Precursors and Cardiomyocytes from Pluripotent Human Embryonic Stem Cells with Small Molecule Induction

Published on: November 3, 2011

Area of Science:

Stem cell biology
Cardiovascular research
Regenerative medicine

Background:

Heart failure treatment is limited by the scarcity of human cardiomyocytes.
Human embryonic stem cells (hESC) are pluripotent and can differentiate into cardiomyocytes.
hESC-derived cardiomyocytes offer a potential solution for cell replacement therapy.

Purpose of the Study:

To review the derivation and properties of hESC lines.
To describe cardiomyocyte differentiation systems using hESC.
To discuss the applications and challenges of hESC-derived cardiomyocytes in cardiac research and therapy.

Main Methods:

Review of existing literature on hESC derivation and differentiation.
Analysis of structural, molecular, and functional properties of hESC-derived cardiomyocytes.
Evaluation of methods for cardiomyocyte enrichment and purification.

Main Results:

hESC can be reliably differentiated into cardiomyocytes.
hESC-derived cardiomyocytes exhibit structural, molecular, and functional characteristics of native cardiomyocytes.
Various differentiation and purification protocols have been established.

Conclusions:

hESC-derived cardiomyocytes hold significant potential for cardiac cell replacement therapy and tissue engineering.
Further research is needed to overcome obstacles for clinical translation.
Harnessing hESC technology can advance cardiovascular regenerative medicine.