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Synthesis of pyrimidine analog of fluoroneplanocin A as potential anti-HCV agent
Hyung-Rock Lee1, Won Hee Kim, Ah-Young Park
1College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 609-735, Korea.
Abstract:
N-hydroxycytosine nucleoside 3 was synthesized as potential anti-HCV agent, starting from D-ribose using an iodine-fluorine exchange reaction by a help of BuLi, a RCM reaction, a stereoselective reduction and a Mitsunobu reaction as the key steps.
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