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Updated: Jul 1, 2026
Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
Our experience in Helicobacter pylori infection and gastric MALToma
T Losacco1, R Cagiano, L Bottalico
1Dept. of Odontostomatology and Surgery, Medical Faculty, University of Bari, Bari, Italy. t.losacco@doc.uniba.it
Objective:
A number of recent studies have expanded our understanding of Helicobacter pylori (Hp) infection and of the pathogenesis of MALT lymphoma. The purpose of this paper is to perform a retrospective analysis of the clinical characteristics of gastric MALT lymphoma and its relationship with H. pylori infection in authors' experience.
Materials And Methods:
We report nineteen patients observed during 10 years, presenting with gastric MALTomas at any stage. The staging classification and the presence of H. pylori infection have been assessed, and the chosen therapy also.
Results:
The most part of our patients underwent surgery, still now resulting the most effective therapy. None of the patients had eradicating therapy due to their poor compliance and because the most part of cases were observed before the time of clinical validation of such treatment.
Conclusions:
In our series, surgery was effective for treatment of gastric MALT lymphomas. Surgery and chemotherapy remain, in accord with literature data, the best treatment for gastric MALTomas. Hence, because Hp may play a role in the development of such pathology in certain patients, antibiotic treatment for Hp eradication should not be discouraged in these patients, especially in them with low grade gastric MALT lymphomas. In fact, the failure of this therapy will not modify either survival or later recourse to surgical and/or radio- and chemotherapy.
Insights
Surgery effectively treated gastric MALT lymphoma in this study. While Helicobacter pylori (Hp) eradication therapy is not discouraged for certain patients, surgery and chemotherapy remain the primary treatments for gastric MALTomas.
Area of Science:
- Gastroenterology
- Oncology
- Infectious Diseases
Background:
- Recent studies have advanced understanding of Helicobacter pylori (Hp) infection and MALT lymphoma pathogenesis.
- Gastric MALT lymphoma is a significant clinical entity linked to Hp infection.
Purpose of the Study:
- To retrospectively analyze the clinical characteristics of gastric MALT lymphoma.
- To investigate the relationship between gastric MALT lymphoma and H. pylori infection.
Main Methods:
- Retrospective analysis of nineteen patients with gastric MALTomas over 10 years.
- Assessment of tumor staging, H. pylori infection status, and treatment modalities.
- Evaluation of surgical and eradicating therapies.
Main Results:
- Surgery was the predominant and effective therapy for most patients.
- No patients received H. pylori eradicating therapy due to poor compliance and treatment validation timing.
- Gastric MALTomas were observed at various stages.
Conclusions:
- Surgery demonstrated effectiveness in treating gastric MALT lymphomas in this series.
- Surgery and chemotherapy are considered the optimal treatments for gastric MALTomas.
- H. pylori eradication therapy should be considered for select patients with low-grade gastric MALT lymphomas, as its failure does not negatively impact survival or subsequent treatments.
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