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MBG/PLGA composite microspheres with prolonged drug release

Xia Li1, Xiupeng Wang, Lingxia Zhang

  • 1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, People's Republic of China.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|September 9, 2008
PubMed

Insights

Mesoporous bioactive glass/poly(D,L-lactide-co-glycolide) composite microspheres offer sustained gentamicin release for over 4 weeks. This makes them promising for bone repair applications, combining antibiotic delivery with bone regeneration properties.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Regenerative Medicine

Background:

  • Mesoporous bioactive glasses (MBG) are investigated for drug delivery.
  • Biodegradable polymers like poly(D,L-lactide-co-glycolide) (PLGA) are used in biomedical applications.
  • Gentamicin (GS) is a common antibiotic for bone infections.

Purpose of the Study:

  • To prepare and characterize MBG and MBG/PLGA composite microspheres for gentamicin loading.
  • To evaluate the in vitro drug release kinetics of gentamicin from these microspheres.
  • To assess the potential of MBG/PLGA composites as drug delivery systems for bone repair.

Main Methods:

  • Preparation of MBG and MBG/PLGA composite microspheres.
  • Loading of gentamicin (GS) into the microspheres.
  • In vitro drug release studies in distilled water and phosphate-buffered saline (PBS) at 37°C for over 30 days.

Main Results:

  • MBG microspheres exhibited rapid GS release: ~60% in 24h and >80% in 2 days.
  • MBG/PLGA composite microspheres showed an initial release of ~33% in 1 day and ~48% in 2 days.
  • Composite microspheres demonstrated sustained GS release for over 4 weeks in PBS.

Conclusions:

  • MBG/PLGA composite microspheres provide sustained antibiotic release, unlike pure MBG.
  • These composites are potential candidates for bone void fillers, offering combined antibiotic delivery and osteoconductive properties.
  • The sustained release profile is advantageous for preventing bone infections and promoting bone healing.

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