Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combinatorial Design of Fatty Acid-Incorporated Plasmid Lipid Nanoparticles Drives Dendritic Cell Hyperactivation for Enhanced Cancer Immunotherapy.

ACS nano·2026
Same author

Cuproptosis Sensitizer Disrupting Mutual Maintenance of Triple Homeostasis for Enhanced Tumor Therapy.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Advances in Bone-on-a-Chips for In Vitro Modeling of Bone Physiology and Pathology.

Biomedicines·2026
Same author

A First-Aid Nanomedicine Endowed with Microenvironment Self-Adaptive Regulation Ability to Facilitate Acute Liver Failure Prophylaxis and Therapy.

ACS nano·2026
Same author

A Biomimetic Nanomedicine for Remodeling the Immune Microenvironment to Potentiating Anti-Tumor Therapy.

Advanced healthcare materials·2025
Same author

Construction of Hierarchical Porous Composite Aerogel for High-Efficient Removal of Low-Level Gaseous Formaldehyde.

Small (Weinheim an der Bergstrasse, Germany)·2025

Related Experiment Video

Updated: May 5, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

6.7K

Engineering Bone-Mimetic Microspheres to Recapitulate the Tumor Microenvironment for In Vitro Osteosarcoma Modeling.

Fangqiao Zheng1,2, Zhengyi Lan2, Hangrong Chen1,2

  • 1School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.

Biomedicines
|May 4, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed bone-mimetic microspheres using microfluidics to model aggressive osteosarcoma (OS) in 3D. These scaffolds enhance OS cell invasion and migration, aiding drug screening and mechanistic studies.

Keywords:
bone-mimetic microspheresdroplet microfluidicsin vitro tumor modelosteosarcomathree-dimensional cell culturetumor microenvironment

More Related Videos

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

9.9K
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

10.1K

Related Experiment Videos

Last Updated: May 5, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

6.7K
A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

9.9K
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

10.1K

Area of Science:

  • Biomaterials Engineering
  • Cancer Biology
  • Microfluidics

Background:

  • Osteosarcoma (OS) is an aggressive bone cancer.
  • Current 3D models lack the native tumor microenvironment, hindering research.
  • Need for physiologically relevant models for OS drug development.

Purpose of the Study:

  • Develop bone-mimetic microspheres for osteosarcoma modeling.
  • Utilize droplet microfluidics for scaffold fabrication.
  • Evaluate OS cell behavior on the novel microsphere platform.

Main Methods:

  • Fabricated bone-mimetic microspheres (MSHA) using microfluidics.
  • MSHA composed of gelatin methacryloyl, PEGDA, and nano-hydroxyapatite (nHA).
  • Cultured MNNG/HOS OS cells on MSHA and assessed bioactivity, stemness, migration, and invasion.

Main Results:

  • Efficient, scalable production of uniform MSHA microspheres.
  • OS cells on MSHA showed high viability and formed tumor spheroids.
  • Enhanced OS cell migration, invasion, and biomarker expression compared to 2D cultures.
  • Nano-hydroxyapatite incorporation amplified malignant phenotypes via ECM-receptor and calcium signaling pathways.

Conclusions:

  • Microfluidics-fabricated MSHA microspheres serve as effective biomimetic 3D scaffolds.
  • These scaffolds show promise for osteosarcoma progression studies.
  • The platform is suitable for osteosarcoma drug screening applications.