Related Experiment Video
Updated: Jul 1, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Targeting prandial hyperglycemia: how important is it and how best to do this?
Louis Monnier1, Claude Colette
1Laboratory of Human Nutrition, University Institute of Clinical Research, 641 Avenue du Doyen Giraud, 34093 Montpellier Cedex 5, France. louis.monnier@inserm.fr
Abstract:
The contribution of postprandial glucose (PPG) excursions to the overall hyperglycemia of patients with type 2 diabetes depends on the degree of diabetic control. PPG is a major contributor in patients with hemoglobin A(1c) (HbA(1c)) levels below 7.3%, whereas the contribution of fasting plasma glucose (FPG) is preponderant in poorly controlled patients. In addition, the loss of postprandial glycemic control precedes stepwise degradation of fasting with worsening diabetes. As a consequence, monitoring after meals is particularly important in patients with HbA(1c) levels ranging from 6.5% to 8%. In such patients, targeting PPG below 140 mg/dL should be one of the main objectives to achieve HbA(1c) less than 6.5%. The new hypoglycemic agents, such as the glucagon-like peptide-1 analogues and the dipeptidyl peptidase-4 inhibitors which have a gluco-dependent insulinotropic effect, should normally reinforce our therapeutic armamentarium for achieving the glycemic targets that should include the three components of the glucose triad: HbA(1c), FPG, and PPG.
Related Concept Videos
Hyperglycemia
Hypoglycemia and Glucagon
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Hypoglycemia
Oral Hypoglycemic Agents: Glinides
Diabetes Mellitus: Type 2 and Gestational
