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Related Concept Videos

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

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Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
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Teasing out T-box targets in early mesoderm.

Fiona C Wardle1, Virginia E Papaioannou

  • 1Department of Physiology, Development and Neuroscience, Downing Street, Cambridge CB2 3DY, UK. fcw27@cam.ac.uk

Current Opinion in Genetics & Development
|September 10, 2008
PubMed
Summary

T-box transcription factors are key regulators in animal development. Recent research reveals their complex interactions with signaling pathways, controlling crucial processes like mesoderm development and body axis formation.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • T-box transcription factors are ancient gene families crucial for metazoan development.
  • The discovery phase for T-box genes is concluding, shifting focus to their regulatory roles.
  • Understanding T-box gene networks is vital for deciphering developmental mechanisms.

Purpose of the Study:

  • To explore the transcriptional targets of T-box transcription factors.
  • To elucidate the role of T-box genes in developmental signaling pathways.
  • To understand the network interactions governing early mesoderm development.

Main Methods:

  • Analysis of mutant phenotypes in mouse and zebrafish models.
  • Utilizing morpholino studies in zebrafish to investigate gene function.
  • Investigating interactions between T-box genes and signaling pathways like Wnt/beta-catenin and Notch/Delta.

Main Results:

  • T-box genes are linked to diverse signaling pathways through their target genes.
  • A network of T-box genes interacts with Wnt/beta-catenin and Notch/Delta pathways.
  • These interactions are critical for mesoderm specification, somite segmentation, and left/right axis determination.

Conclusions:

  • T-box transcription factors play a central role in orchestrating early developmental processes.
  • The interplay between T-box genes and signaling pathways forms a complex regulatory network.
  • Further research into T-box targets will yield significant insights into developmental biology.