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Updated: Jul 1, 2026
Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model
Published on: September 9, 2011
Testing percutaneous arterial closure devices: an animal model
Rui-Fang Ni1, Pawanrat Kranokpiraksa, Dusan Pavcnik
1Dotter Interventional Institute, Oregon Health Sciences University, Portland, OR 97201, USA.
Abstract:
The ovine superficial femoral artery was used for testing the efficacy of percutaneous arterial closure devices (PACDs) in their developmental stage. Two topical devices containing chitostan, one staple-mediated PACD and a porcine small intestinal submucosa plug, were tested by follow-up angiography in 37 sheep. Absence or presence of bleeding and time to bleeding cessation were the main criteria for evaluation of PAVD efficacy. The results of these tests directed modification of individual PACDs and improved their efficacy.
