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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
The Bone Matrix01:18

The Bone Matrix

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TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
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Bone Cells and Tissue

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Related Experiment Video

Updated: Jul 1, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

Titanium acts on osteoblast translational process.

Annalisa Palmieri1, Furio Pezzetti, Anna Avantaggiato

  • 1Institute of Histology, University of Bologna and Center of Molecular Genetics, Cassa di Risparmio di Bologna Foundation, Bologna, Italy.

The Journal of Oral Implantology
|September 11, 2008
PubMed
Summary

Titanium enhances bone formation by regulating osteoblast activity. This study identified specific microRNAs (miRNAs) that are upregulated or downregulated in osteoblasts grown on titanium, offering insights into bone healing mechanisms.

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Area of Science:

  • Biomaterials Science
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Titanium is a biocompatible and osteogenic material used in implants.
  • The precise mechanisms by which titanium influences osteoblast activity and bone formation are not fully understood.

Purpose of the Study:

  • To investigate the role of microRNA (miRNA) in regulating osteoblast gene expression on titanium surfaces.
  • To identify specific miRNAs affected by titanium exposure in osteoblasts.

Main Methods:

  • Utilized miRNA oligonucleotide microarray analysis with 329 probes.
  • Examined miRNA profiles in the MG-63 osteoblast-like cell line cultured on titanium disks.

Main Results:

  • Identified 13 upregulated miRNAs, including miR-23a, miR-222, and miR-26a.
  • Identified 2 downregulated miRNAs: miR-187 and miR-339.
  • This is the first study to report on miRNA-mediated translation regulation in osteoblasts exposed to titanium.

Conclusions:

  • Titanium exposure significantly alters miRNA expression in osteoblasts.
  • These findings provide a foundation for understanding the molecular mechanisms of titanium-induced osteoblast activation.
  • The identified miRNAs may serve as biomarkers or therapeutic targets for enhancing bone regeneration.