Related Experiment Video
Updated: Jul 1, 2026
08:16
One-anastomosis Gastric Bypass (OAGB) in Rats
Published on: November 10, 2018
Rat gastric banding model for bariatric surgery
Hitoshi Kanno1, Teruo Kiyama, Itsuo Fujita
1Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan. s6023@nms.ac.jp
Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
|September 11, 2008
Summary
Adjustable gastric banding in rats reduced weight gain by decreasing food intake due to a smaller stomach pouch. This surgical weight reduction model provides insights into bariatric surgery mechanisms.
Area of Science:
- Bariatric Surgery
- Animal Models
- Weight Management
Background:
- Adjustable gastric banding is a surgical method for weight reduction.
- A rat model was developed to study the mechanisms of body weight loss following gastric banding.
Purpose of the Study:
- To investigate the effects of adjustable gastric banding on body weight, food intake, water intake, and nitrogen balance in a rat model.
- To understand the physiological mechanisms underlying weight loss induced by gastric banding.
Main Methods:
- Male Sprague-Dawley rats (260-280g) underwent either gastric banding (n=8) or a sham operation (control, n=8).
- Body weights were monitored for 14 days.
- Food and water intake, and nitrogen balance were monitored for 7 days post-operation.
Main Results:
- Gastric banding led to significantly reduced body weight gain compared to controls (p<0.01).
- Food and water intake were significantly decreased in the band group (p<0.01).
- Nitrogen balance was significantly lower in the band group (p<0.01), with two deaths due to obstruction.
Conclusions:
- Adjustable gastric banding effectively decreased body weight gain in rats.
- Reduced food intake, caused by the creation of a small gastric pouch, is the primary mechanism for weight loss.
- The model highlights potential complications like gastric stomal stenosis and obstruction.
