A novel glucose sensor based on monodispersed Ni/Al layered double hydroxide and chitosan

Area of Science:

• Electrochemistry
• Materials Science
• Biotechnology

Background:

• Development of efficient and cost-effective biosensors for glucose detection is crucial for diabetes management.
• Traditional glucose biosensors often rely on enzymes like glucose oxidase, which can be costly and unstable.
• Nanomaterials offer unique properties for enhancing biosensor performance.

Purpose of the Study:

• To present a novel, low-cost amperometric glucose biosensor.
• To utilize nickel/aluminum layered double hydroxide (Ni/Al-LDH) nanoflakes and chitosan (CHT) for electrode modification.
• To evaluate the performance of the biosensor without the need for glucose oxidase.

Main Methods:

• Electrode modification with Ni/Al-LDH nanoflakes and chitosan (CHT).
• Amperometric detection of glucose at a specific applied potential (0.48V).
• Optimization of biosensor construction, applied potential, and scan rate.
• Investigation of interference effects and analysis of human serum samples.

Main Results:

• The Ni/Al-LDH/CHT modified electrode demonstrated effective glucose sensing.
• The biosensor exhibited a linear detection range of 0.01-10 mM.
• The sensor showed good operational stability and a rapid response time.

Conclusions:

• A cost-effective and simple amperometric glucose biosensor was successfully developed.
• The Ni/Al-LDH/CHT composite is a promising material for enzyme-free glucose detection.
• The developed biosensor shows potential for practical applications in glucose monitoring.