Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
Ventilatory Modes01:14

Ventilatory Modes

Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Pulmonary Ventilation: Inhalation01:24

Pulmonary Ventilation: Inhalation

Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
Pressure Relationships in Thoracic Cavity01:24

Pressure Relationships in Thoracic Cavity

Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs during...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frailty, Geriatric Impairments, and Quality of Life in Older Cancer Survivors Compared to Age-Matched Non-Cancer Controls.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same author

Update from the 5th Edition of the WHO Classification of Nasal, Paranasal, and Skull Base Tumors: Imaging Overview with Histopathologic and Genetic Correlation.

AJNR. American journal of neuroradiology·2023
Same author

Unpacking the CNS Manifestations of Epstein-Barr Virus: An Imaging Perspective.

AJNR. American journal of neuroradiology·2023
Same author

Amino Acid Tracer PET MRI in Glioma Management: What a Neuroradiologist Needs to Know.

AJNR. American journal of neuroradiology·2023
Same author

Diagnostic Performance of PET and Perfusion-Weighted Imaging in Differentiating Tumor Recurrence or Progression from Radiation Necrosis in Posttreatment Gliomas: A Review of Literature.

AJNR. American journal of neuroradiology·2020
Same author

Retrospective, dual-centre review of imaging findings in neurosarcoidosis at presentation: prevalence and imaging sub-types.

Clinical radiology·2020

Related Experiment Video

Updated: Jul 1, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

Positive pressure ventilation: what is the real cost?

N Soni1, P Williams

  • 1Imperial College Medical School, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK. n.soni@imperial.ac.uk

British Journal of Anaesthesia
|September 11, 2008
PubMed
Summary

Positive pressure ventilation significantly alters lung physiology, potentially causing complications with prolonged use. Exploring alternatives like oxygen supplementation for a rested lung may offer a more rational approach to patient care.

Related Experiment Videos

Last Updated: Jul 1, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

Area of Science:

  • Physiology
  • Respiratory Medicine
  • Critical Care

Background:

  • Positive pressure ventilation (PPV) deviates from spontaneous breathing physiology.
  • Immediate hemodynamic effects of PPV are understood, but insidious interactions with prolonged use are less recognized.

Purpose of the Study:

  • To explore the less obvious physiological consequences of positive pressure ventilation.
  • To investigate potential alternative ventilation strategies for improved patient outcomes.

Main Methods:

  • Review of physiological interactions between PPV, airway resistance, and alveolar compliance.
  • Analysis of effects on gas flow distribution, capillary perfusion, and fluid balance.
  • Consideration of hydrostatic forces and lymphatic drainage impacts.

Main Results:

  • PPV causes uneven ventilation distribution and affects capillary perfusion.
  • Raised intrathoracic and central venous pressures impair lymphatic drainage, leading to fluid sequestration.
  • Positive end-expiratory pressure (PEEP) can exacerbate physiological derangements.

Conclusions:

  • Avoiding PPV in rested lungs may benefit lung and organ function.
  • Oxygen supplementation of a physiologically neutral lung is a potential alternative.
  • Shifting from aggressive PPV to less invasive methods may represent a more rational future practice.