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Androgen receptor CAG repeat polymorphisms in canine prostate cancer
C-L Lai1, H L'Eplattenier, R van den Ham
1Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, TD Utrecht, The Netherlands.
Journal of Veterinary Internal Medicine
|September 12, 2008
Summary
Shorter CAG-1 repeats in the androgen receptor (AR) gene are linked to a higher risk of prostate cancer (PC) in dogs. This study explored the association between AR gene CAG repeat lengths and PC development in canine subjects.
Area of Science:
- Canine genetics
- Comparative oncology
- Molecular biology
Background:
- Androgen receptor (AR) gene CAG repeat lengths are implicated in human prostate cancer (PC) risk.
- The canine AR gene possesses two polymorphic CAG repeat (CAGr) regions.
Purpose of the Study:
- To investigate the association between canine AR gene CAG repeat length and the incidence of PC.
- To determine if CAGr length variations correlate with PC development in dogs.
Main Methods:
- DNA analysis of 32 dogs with PC and 172 control dogs.
- Polymerase chain reaction (PCR) amplification and sequencing of AR gene CAG repeats from blood DNA.
Main Results:
- Dogs with PC exhibited shorter CAG-1 repeat lengths compared to controls (P = .001).
- Specific CAG-1 repeat lengths (10 repeats, P = .011; absence of 12 repeats, P = .0017) were more prevalent in dogs with PC.
- No significant association was found between CAG-3 repeat length and PC; CAG-1 and CAG-3 polymorphisms were not in linkage disequilibrium.
Conclusions:
- Preliminary findings suggest a correlation between shorter CAG-1 repeats in the AR gene and an increased risk of canine PC.
- While breed-specific differences in CAG repeat distribution exist, they were not directly linked to PC risk in this study.
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