Related Experiment Video
Updated: Jul 1, 2026

08:17
Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
Published on: September 22, 2017
Folic acid deficiency optic neuropathy: a case report
Punyanganie de Silva1, Gerard Jayamanne, Robin Bolton
1Doncaster Royal Infirmary, Doncaster, UK. punyanganie@yahoo.com
Journal of Medical Case Reports
|September 12, 2008
Summary
Severe folate deficiency can cause vision loss. Prompt supplementation improved visual acuity in a patient with this rare nutritional optic neuropathy, highlighting its importance for general physicians.
Area of Science:
- Ophthalmology
- Neurology
- Nutritional Science
Background:
- Nutritional optic neuropathies are rare causes of vision impairment.
- They can manifest as gradual vision loss with optic atrophy or sudden vision loss with optic disc swelling.
Purpose of the Study:
- To report an unusual case of nutritional optic neuropathy.
- To highlight the clinical presentation and management of folate deficiency presenting as optic neuropathy.
Main Methods:
- A case study of a 44-year-old woman with progressive visual loss.
- Diagnostic investigations revealed severe folate deficiency.
- Treatment involved oral folate supplementation.
Main Results:
- The patient presented with bilateral retrobulbar optic neuropathy.
- Severe folate deficiency was identified, with normal vitamin B12 levels.
- Visual acuity improved following folate level correction.
Conclusions:
- Folic acid deficiency can present atypically with optic neuropathy.
- This case underscores the need for general physicians to consider nutritional deficiencies in patients with visual disturbances.
Related Concept Videos
Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

