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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: Jul 1, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Osteoporosis in developing countries.

Rohini Handa1, Asgar Ali Kalla, Ghassan Maalouf

  • 1Clinical Immunology & Rheumatology Service, All India Institute of Medical Sciences, New Delhi, India. rohinihanda@hotmail.com

Best Practice & Research. Clinical Rheumatology
|September 12, 2008
PubMed
Summary
This summary is machine-generated.

Osteoporosis is a major health challenge in developing nations, particularly with aging populations and scarce resources. The World Health Organization offers a fracture risk assessment tool usable even without bone density measurements.

Related Experiment Videos

Last Updated: Jul 1, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

Area of Science:

  • Gerontology
  • Public Health
  • Orthopedics

Background:

  • Osteoporosis presents a significant challenge in developing countries, exacerbated by aging populations and limited resources.
  • Accurate disease burden quantification is hindered by a lack of data, with ethnicity impacting bone density and fracture risk.
  • Population-specific bone density data are scarce globally, and Vitamin D deficiency is prevalent even in sunny regions.

Purpose of the Study:

  • To highlight the challenges of osteoporosis management in developing countries.
  • To underscore the need for accessible fracture risk assessment tools.

Main Methods:

  • Review of existing data and challenges in osteoporosis assessment.
  • Discussion of the World Health Organization's 10-year fracture risk estimation algorithm.

Main Results:

  • Developing countries face unique osteoporosis challenges due to demographic shifts and resource limitations.
  • Ethnic variations influence bone density and fracture susceptibility.
  • Vitamin D deficiency is a widespread issue, even in sun-rich areas.

Conclusions:

  • The World Health Organization's fracture risk algorithm provides a valuable tool for osteoporosis assessment in resource-limited settings, especially when bone mineral density is unavailable.
  • Addressing osteoporosis in developing nations requires tailored strategies considering data scarcity and ethnic variations.