Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of the dermatologist in Raynaud's phenomenon: a clinical challenge.

Journal of the European Academy of Dermatology and Venereology : JEADV·2018
Same author

There is a need for new systemic sclerosis subset criteria. A content analytic approach.

Scandinavian journal of rheumatology·2017
Same author

Assessment of vascular involvement.

Clinical and experimental rheumatology·2003
Same author

An elderly man with vasculitis and IgA myeloma.

Journal of the European Academy of Dermatology and Venereology : JEADV·1998
Same author

Raynaud's phenomenon and systemic sclerosis.

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna·1996
Same author

Sarcoidosis in systemic sclerosis: report of 7 cases.

The Journal of rheumatology·1995
Same journal

Vaccination coverage of influenza and pneumococcal vaccines in patients with rheumatic diseases: a systematic review and meta-analysis.

Rheumatology (Oxford, England)·2026
Same journal

Comment on: Distinct cytokine and cytokine receptor expression patterns characterise different forms of myositis.

Rheumatology (Oxford, England)·2026
Same journal

A Delphi survey of patients and clinicians on a unified and stratified approach to managing GCA-PMR spectrum disease.

Rheumatology (Oxford, England)·2026
Same journal

Cardiac involvement in Behçet's syndrome: findings from a clinically driven cardiological evaluation.

Rheumatology (Oxford, England)·2026
Same journal

Mechanisms, clinical manifestations and management of cardiovascular diseases in ANCA-associated vasculitis.

Rheumatology (Oxford, England)·2026
Same journal

Clinical and autoantibody associations with malignancy in systemic sclerosis: A systematic review and meta-analysis.

Rheumatology (Oxford, England)·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2026

Using a Laminating Technique to Perform Confocal Microscopy of the Human Sclera
07:22

Using a Laminating Technique to Perform Confocal Microscopy of the Human Sclera

Published on: May 6, 2016

The microvascular endothelium in scleroderma.

B Kahaleh1

  • 1Division of Rheumatology and Immunology, University of Toledo College of Medicine, 3120 Glendale Ave, Toledo, OH 43617, USA. bashar.kahaleh@utoledo.edu

Rheumatology (Oxford, England)
|September 17, 2008
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis (SSc) causes vascular injury and chronic tissue ischemia. Understanding immune triggers may lead to new therapeutic strategies for SSc vascular disease.

More Related Videos

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

Quantifying Pulmonary Microvascular Density in Mice Across Lobules
10:00

Quantifying Pulmonary Microvascular Density in Mice Across Lobules

Published on: January 3, 2025

Related Experiment Videos

Last Updated: Jul 1, 2026

Using a Laminating Technique to Perform Confocal Microscopy of the Human Sclera
07:22

Using a Laminating Technique to Perform Confocal Microscopy of the Human Sclera

Published on: May 6, 2016

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

Quantifying Pulmonary Microvascular Density in Mice Across Lobules
10:00

Quantifying Pulmonary Microvascular Density in Mice Across Lobules

Published on: January 3, 2025

Area of Science:

  • Immunology
  • Vascular Biology
  • Rheumatology

Background:

  • Systemic sclerosis (SSc) is characterized by vascular endothelial injury.
  • This injury leads to pathological changes in blood vessels, impacting organ systems and causing chronic tissue ischemia.
  • Current hypotheses suggest immune system activation as a key factor in SSc vascular disease pathogenesis.

Purpose of the Study:

  • To explore the potential infectious or chemical triggers of immune activation in SSc.
  • To understand how immune activation contributes to vascular injury in SSc.
  • To identify opportunities for developing multi-step therapeutic interventions for SSc vascular disease.

Main Methods:

  • Review of current hypotheses on SSc vascular disease pathogenesis.
  • Analysis of the role of cellular and humoral immunity in SSc.
  • Examination of autoantibody production and T cell activation in endothelial damage.

Main Results:

  • Immune activation, potentially triggered by infectious or chemical agents, is implicated in SSc vascular disease.
  • Products of immune activation, including autoantibodies and T cell products, may directly damage the endothelium.
  • Vascular endothelial injury in SSc results in widespread pathological changes and chronic tissue ischemia.

Conclusions:

  • Identifying the initial trigger of immune activation in SSc is crucial.
  • This knowledge can inform the development of targeted, multi-step therapeutic strategies.
  • Interventions aimed at modulating the immune response may offer a novel approach to treating SSc vascular complications.